Targeted inhibition of mTOR by BML-275 induces mitochondrial-mediated apoptosis and autophagy in prostate cancer
Wangjian Li, Dongzhang Li, Quan Ma, Yongliang Chen, Zujian Hu, Yongheng Bai, Liping Xie
Topics & Concepts
PI3K/AKT/mTOR pathwayAutophagyApoptosisProtein kinase BRPTORCancer researchAMPKProgrammed cell deathSurvivinCell growthBiologyCyclin D1Cell biologyProstate cancerCell cycleChemistryCancerKinaseProtein kinase ABiochemistryGeneticsAutophagy in Disease and TherapyCancer-related Molecular PathwaysHistone Deacetylase Inhibitors Research