MyD88 signaling by neurons induces chemokines that recruit protective leukocytes to the virus-infected CNS
Luca Ghita, Julia Spanier, Chintan Chhatbar, Felix Mulenge, Andreas Pavlou, Pia-Katharina Larsen, Inken Waltl, Yvonne Lueder, Moritz Kohls, Klaus Jung, Sonja M. Best, Reinhold Förster, Martin Stangel, Dietmar Schreiner, Ulrich Kalinke
Abstract
T cells, protected against lethal VSV infection of the CNS. Reconstitution of MyD88, specifically in neurons, restored chemokine production in the olfactory bulb as well as leukocyte recruitment into the infected CNS and enhanced survival. Comparative analysis of the translatome of neurons and astrocytes verified neurons as the critical source of chemokines, which regulated leukocyte infiltration of the infected brain and affected survival.
Topics & Concepts
ChemokineImmune systemBiologyImmunologyVirusSignal transductionInflammationViral infectionCell biologyinterferon and immune responsesImmune Response and InflammationNeuroinflammation and Neurodegeneration Mechanisms