Okadaic acid influences xenobiotic metabolism in HepaRG cells
Leonie T. D. Wuerger, Helen Hammer, Ute Hofmann, Felicia Kudiabor, Holger Sieg, Albert Braeuning
Abstract
at non-cytotoxic concentrations. The interplay of OA with known CYP inducers was also studied. Data show that the expression of various xenobiotic-metabolizing CYPs was downregulated after exposure to OA. Moreover, OA was able to counteract the activation of CYPs by their inducers. A number of transporters were also mainly downregulated. Overall, we demonstrate that OA has a significant effect on xenobiotic metabolism barrier in liver cells, highlighting the possibility for interactions of OA exposure with the metabolism of drugs and xenobiotics.
Topics & Concepts
XenobioticOkadaic acidDrug metabolismCytochrome P450ToxicityPharmacologyMetabolismChemistryBiologyGenotoxicityBiochemistryEnzymePhosphataseOrganic chemistryMarine Toxins and Detection MethodsAlcohol Consumption and Health EffectsEicosanoids and Hypertension Pharmacology