Kongensin A targeting PI3K attenuates inflammation-induced osteoarthritis by modulating macrophage polarization and alleviating inflammatory signaling
Yuhui Guo, Peng Wang, Binwu Hu, Ling Wang, Yingze Zhang, Juan Wang, Juan Wang
Topics & Concepts
Macrophage polarizationChondrocytePI3K/AKT/mTOR pathwayInflammationProtein kinase BAnabolismSenescenceCell biologyCartilageOsteoarthritisCancer researchMacrophageExtracellular matrixChemistrySignal transductionBiologyImmunologyMedicinePathologyIn vitroBiochemistryAnatomyAlternative medicineOsteoarthritis Treatment and MechanismsInflammatory mediators and NSAID effectsChemokine receptors and signaling