miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells
Clarice X. Lim, Bernett Lee, Olivia Geiger, Christina Passegger, Michaela Beitzinger, Johann Romberger, Anika Stracke, Christoph Högenauer, Anton Stift, Heribert Stoiber, Michael Poidinger, Armin Zebisch, Gunter Meister, Adam Williams, Richard A. Flavell, Jorge Henao‐Mejia, Herbert Strobl
Abstract
mo-DCs. Collectively, our study demonstrates that high DC-SIGN expression levels and a high activation threshold in mo-DCs are linked and simultaneously maintained by miR-181a.
Topics & Concepts
DC-SIGNProinflammatory cytokineMAPK/ERK pathwayCell biologyDendritic cellSignal transductionMonocyteBiologyChemistryImmune systemImmunologyInflammationImmunotherapy and Immune ResponsesImmune Response and InflammationImmune cells in cancer