Inflammation causes remodeling of mitochondrial cytochrome <i>c</i> oxidase mediated by the bifunctional gene <i>C15orf48</i>
Sally A. Clayton, Kalbinder K Daley, Lucy MacDonald, Erika Fernández‐Vizarra, Giovanni Bottegoni, John D. O’Neil, Triin Major, Daniel Griffin, Qinqin Zhuang, Adeolu B. Adewoye, Kieran Woolcock, Simon W. Jones, Carl S. Goodyear, Aziza Elmesmari, Andrew Filer, Daniel A. Tennant, Stefano Alivernini, Christopher D. Buckley, Robert D. S. Pitceathly, Mariola Kurowska‐Stolarska, Andrew R. Clark
Abstract
is also expressed by pathogenic macrophages in severe coronavirus disease 2019 (COVID-19). Study of a rare metabolic disease syndrome provides evidence that loss of the NDUFA4 subunit supports proinflammatory macrophage functions.
Topics & Concepts
Cytochrome c oxidaseInflammationMitochondrionGeneCytochromeCell biologyBiologyChemistryBiochemistryEnzymeImmunologyMitochondrial Function and PathologyNeutrophil, Myeloperoxidase and Oxidative MechanismsCancer, Hypoxia, and Metabolism