Novel 1,2,4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study
Tarek S. Ibrahim, Ahmad J. Almalki, Amr H. Moustafa, Rasha M. Allam, Gamal El‐Din A. Abuo‐Rahma, Hussein I. El‐Subbagh, Mamdouh F. A. Mohamed
Topics & Concepts
DNA gyraseChemistryNovobiocinCiprofloxacinDocking (animal)Antibacterial activityChalconeMinimum inhibitory concentrationStereochemistryMicroscale thermophoresisEscherichia coliNalidixic acidOximeIC50BiochemistryIn vitroBacteriaAntibioticsBiologyMedicineGeneGeneticsNursingSynthesis and biological activitySynthesis and Biological EvaluationCancer therapeutics and mechanisms