BRD4 inhibition by JQ1 prevents high-fat diet-induced diabetic cardiomyopathy by activating PINK1/Parkin-mediated mitophagy in vivo
Jing Mu, Donghong Zhang, YunLi Tian, Zhonglin Xie, Ming‐Hui Zou
Topics & Concepts
MitophagyDiabetic cardiomyopathyParkinCardiomyopathyPINK1Cardiac function curveMedicineBRD4Heart failureInternal medicineEndocrinologyAutophagyEpigeneticsBromodomainChemistryDiseaseParkinson's diseaseBiochemistryApoptosisGeneProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathways