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Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor

Honghui Zhang, Tailai Chen, Keliang Wu, Zhenzhen Hou, Shigang Zhao, Chuanxin Zhang, Yuan Gao, Ming Gao, Zi‐Jiang Chen, Han Zhao

2021Cell Research27 citationsDOIOpen Access PDF

Topics & Concepts

ZygoteBiologyCHEK1MutationCell biologyGeneticsCell cycle checkpointEmbryoCell cycleGeneEmbryogenesisCRISPR and Genetic EngineeringDNA Repair MechanismsMicrotubule and mitosis dynamics
Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor | Litcius