STC-15, an oral small molecule inhibitor of the RNA methyltransferase METTL3, inhibits tumour growth through activation of anti-cancer immune responses associated with increased interferon signalling, and synergises with T cell checkpoint blockade

Yaara Ofir-Rosenfeld, L. Vasiliauskaitė, C. Saunders, A. Sapetschnig, G. Tsagkogeorga, M. Albertella, M. Carkill, J. Self-Fordham, J.B. Holz, O. Rausch