Multi-Responsive Silk Fibroin-Based Nanoparticles for Drug Delivery
Ya Ma, Brandon S.B. Canup, Xiaoling Tong, Fangyin Dai, Bo Xiao
Abstract
Silk fibroin has the merits of biocompatibility, biodegradability, ease of processing, and feasibility of modification, which present it as a promising drug delivery material. This review focuses on the structures of silk fibroin, the controlled transformation of secondary structures, and the formation mechanism of silk fibroin-based nanoparticles (SFNPs). We also discuss the intrinsic multi-responsive, surface functionalization, and transgenic modification of SFNPs for drug delivery.
Topics & Concepts
FibroinDrug deliveryNanoparticleNanotechnologyDrugMaterials scienceChemistrySILKPharmacologyMedicineComposite materialSilk-based biomaterials and applicationsBiochemical and Structural CharacterizationAntimicrobial Peptides and Activities