Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models
Marcel Schneider, Laura Heeb, Michał Beffinger, Stanislav Pantelyushin, Michael Linecker, Lilian Roth, Kuno Lehmann, U. Ungethüm, Sebastian Kobold, Rolf Graf, Maries van den Broek, Johannes vom Berg, Anurag Gupta, Pierre‐Alain Clavien
Abstract
T cells within tumors. Clinically approved serotonin targeting agents alone or in combination with PD-1 blockade provided long-term control of established tumors in murine models, warranting further investigation of the clinical translatability of these findings.
Topics & Concepts
SerotoninPancreatic cancerCD8Cancer researchTumor microenvironmentMedicineInternal medicineEndocrinologyCancerChemistryBiologyImmune systemReceptorImmunologyCancer, Stress, Anesthesia, and Immune ResponseCancer Immunotherapy and BiomarkersCancer Cells and Metastasis