Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding
Takuma Yasuda, Norio Harada, Tomonobu Hatoko, Atsuhiko Ichimura, Eri Ikeguchi-Ogura, Yuki Murata, Naoki Wada, Sakura Kiyobayashi, Shunsuke Yamane, Akira Hirasawa, Nobuya Inagaki
Abstract
We generated novel intestine-specific GPR120-knockout ( GPR120 int−/− ) mice and investigated the metabolic effect of GPR120 in the intestine. GPR120 int−/− mice exhibited a reduction of GIP secretion and CCK action after a single administration of LCT. Under a high-LCT diet, GPR120 int−/− mice showed mild improvement in obesity and marked amelioration of insulin resistance and hepatic steatosis. Our results indicate an important role of intestinal GPR120 on insulin resistance and hepatic steatosis.
Topics & Concepts
GPR120Internal medicineSteatosisInsulin resistanceEndocrinologyDiabetes mellitusSmall intestineFatty liverInsulinBiologyReceptorMedicineDiseaseG protein-coupled receptorDiabetes Treatment and ManagementMetabolism, Diabetes, and CancerRegulation of Appetite and Obesity