Advanced brain age in community-dwelling population with combined physical and cognitive impairments
Chen-Yuan Kuo, Pei‐Lin Lee, Li‐Ning Peng, Wei‐Ju Lee, Pei‐Ning Wang, Liang‐Kung Chen, Kun‐Hsien Chou, Chih‐Ping Chung, Ching‐Po Lin
Abstract
We investigated whether advanced brain biological age is associated with accelerated age-related physical and/or cognitive functional decline: mobility impairment no disability (MIND), cognitive impairment no dementia (CIND) and physio-cognitive decline syndrome (PCDS). We constructed a brain-age prediction model using gray-matter features from the MRI of 1,482 healthy individuals (age: 18-92 years). Predicted and chronological age differences were obtained (brain-age-gap; BAG) and analyzed in another 1,193 community-dwelling population aged ≥ 50 years. Among the 1,193 participants, there were 501, 346, 148, and 198 in the robust, CIND, MIND, and PCDS groups, respectively. Participants with PCDS had significantly larger BAG (BAG = 2.99±8.97) than the robust (BAG = -0.49±9.27, p = 0.002; η2 = 0.014), CIND (BAG = 0.47±9.16, p = 0.02; η2 = 0.01), and MIND (BAG = 0.36±9.69, p = 0.036; η2 = 0.013) groups. Advanced brain aging is involved in the pathophysiology of the co-occurrence of physical and cognitive decline in the older people. The PCDS may be a clinical phenotype reflective of accelerated biological age in community-dwelling older individuals. Data supporting the present findings are available upon reasonable request.