The GPER1/SPOP axis mediates ubiquitination-dependent degradation of ERα to inhibit the growth of breast cancer induced by oestrogen
Nan Zhang, Peng Sun, Yuanyuan Xu, Haiyan Li, Huatao Liu, Lingling Wang, Yue Cao, Kewen Zhou, TinghuaiWang
Topics & Concepts
Ubiquitin ligaseUbiquitinCancer researchEstrogen receptorBreast cancerDownregulation and upregulationBiologyEstrogen receptor alphaReceptorProteasomeEndocrinologyInternal medicineCancerCell biologyMedicineGeneBiochemistryEstrogen and related hormone effectsRetinoids in leukemia and cellular processesReceptor Mechanisms and Signaling