Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies
Matheus Ferraz, Emerson G. Moreira, Danilo F. Coêlho, Gabriel Luz Wallau, Roberto D. Lins
Abstract
SARS-CoV-2 VOC immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOCs is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. The P.3 variant is a putative VOC.
Topics & Concepts
AntibodyEvasion (ethics)Immune escapeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Immune systemVirologyCoronavirus disease 2019 (COVID-19)Neutralizing antibody2019-20 coronavirus outbreakNeutralizationBiologyChemistryImmunologyMedicineInfectious disease (medical specialty)DiseasePathologyOutbreakSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesInhalation and Respiratory Drug Delivery