Modular Synthesis of α,α-Diaryl α-Amino Esters via Bi(V)-Mediated Arylation/S<sub>N</sub>2-Displacement of Kukhtin–Ramirez Intermediates
Alessio Calcatelli, Ross M. Denton, Liam T. Ball
Abstract
2 displacement by an amine. The methodology is compatible with a wide range of anilines and primary amines - including derivatives of drugs and proteinogenic amino acids - Bi(V) arylating agents, and α-keto ester substrates.
Topics & Concepts
ChemistryElectrophileSN2 reactionUmpolungAmine gas treatingAmino acidCombinatorial chemistryKetoneModular designStereochemistryMedicinal chemistryOrganic chemistryCatalysisNucleophileOperating systemComputer scienceBiochemistryCyclopropane Reaction MechanismsAsymmetric Synthesis and CatalysisChemical Synthesis and Analysis