An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver
Jain Jeong, Masatake Tanaka, Yilin Yang, Nikolai Arefyev, Jenna DiRito, Gregory T. Tietjen, Xuchen Zhang, Matthew J. McConnell, Teruo Utsumi, Yasuko Iwakiri
2023American Journal of Physiology-Gastrointestinal and Liver Physiology10 citationsDOIOpen Access PDF
Abstract
This article showed a comprehensive 3-D-structural analysis of liver lymphatic vessel (LV) in normal and diseased livers in relation to blood vessels and bile ducts. In addition to the LVs highly localized at the portal tract, we revealed capsular LVs in mouse, rat, and human livers. In cholestatic livers, LVs are significantly increased and dilated compared with normal livers. Our optimized protocol provides detailed spatial information for LVs remodeling in normal and pathological conditions.
Topics & Concepts
Lymphatic systemLymphatic vesselPathologyBiologyAnatomyMedicineInternal medicineMetastasisCancerLymphatic System and DiseasesCerebrospinal fluid and hydrocephalusGenetic and Kidney Cyst Diseases