AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific T <sub>H</sub> 1 response with a diverse TCR repertoire
Phillip A. Swanson, Marcelino Padilla, Wesley Hoyland, Kelly McGlinchey, Paul Fields, Sagida Bibi, Saul N. Faust, Adrian B. McDermott, Teresa Lambe, Andrew J. Pollard, Nicholas M. Durham, Elizabeth J. Kelly, AstraZeneca/Oxford/VRC Study Group
Abstract
Polyfunctional CD4 + and CD8 + T cell responses are elicited against the SARS-CoV-2 spike protein after two doses of the AZD1222 COVID-19 vaccine.
Topics & Concepts
Spike (software development)VaccinationRepertoireSpike ProteinT-cell receptorSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyCoronavirus disease 2019 (COVID-19)Biology2019-20 coronavirus outbreakBetacoronavirusImmunologyComputational biologyMedicineImmune systemComputer scienceT cellPhysicsOutbreakDiseasePathologyInfectious disease (medical specialty)Software engineeringAcousticsCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionSARS-CoV-2 and COVID-19 Research