Circadian clock modulating small molecules repurposing as inhibitors of SARS-CoV-2 M<sup>pro</sup> for pharmacological interventions in COVID-19 pandemic
Armiya Sultan, Rafat Ali, Tahira Sultan, Sher Ali, Nida Jamil Khan, Arti Parganiha
Abstract
to block the replication of SARS-CoV-2. The findings are expected to pave the way for the development of therapeutics for COVID-19.
Topics & Concepts
Drug repositioningCoronavirusViral replicationPandemicPolyproteinsRepurposingCoronavirus disease 2019 (COVID-19)Circadian clockVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Drug discoveryProteaseBiologyComputational biologyDrugCircadian rhythmPharmacologyMedicineBioinformaticsVirusNeuroscienceEnzymeInfectious disease (medical specialty)Internal medicineBiochemistryDiseaseEcologySARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery MethodsViral gastroenteritis research and epidemiology