Elevated bile acid metabolism and microbiome are associated with suppressed cell proliferation and better survival in breast cancer.
Rongrong Wu, Irene Yu, Yoshihisa Tokumaru, Mariko Asaoka, Masanori Oshi, Li Yan, Shujiro Okuda, Takashi Ishikawa, Kazuaki Takabe
Abstract
in the low metabolism group. Surprisingly, almost all Hallmark cell proliferation-associated gene sets were highly enriched in all three microorganisms that were abundant in the low bile acid metabolism group. In conclusion, microorganisms abundant in the breast tumor microenvironment with low bile acid metabolism are associated with aggressive cancer biology, including increased cell proliferation and poor survival.
Topics & Concepts
Breast cancerDeoxycholic acidMicrobiomeBiologyBile acidMetabolismCancer researchCholic acidCancerColorectal cancerTranscriptomeCell growthInternal medicineEndocrinologyGeneMedicineBioinformaticsGene expressionBiochemistryGeneticsEpigenetics and DNA MethylationDrug Transport and Resistance MechanismsFerroptosis and cancer prognosis