Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Keyuree Satam, Yuichi Ohashi, Carly Thaxton, Luis Gonzalez, Ocean Setia, Hualong Bai, Yukihiko Aoyagi, Yangzhouyun Xie, Weichang Zhang, Bogdan Yatsula, Kathleen A. Martin, Yujun Cai, Alan Dardik
Abstract
After arteriovenous fistula creation, females have lower rates of maturation and higher rates of failure than males. In a mouse model of venous adaptation that recapitulates human fistula maturation, sex hormones may be mechanisms of the sexual dimorphism: testosterone is associated with reduced shear stress, whereas estrogen is associated with increased immune cell recruitment. Modulating sex hormones or downstream effectors suggests sex-specific therapies and could address disparities in sex differences in clinical outcomes.
Topics & Concepts
HormoneImmune systemTestosterone (patch)EstrogenSexual dimorphismAndrogenBiologyArteriovenous fistulaSex hormone-binding globulinInternal medicineSex hormone receptorSex steroidPhysiologyEndocrinologyEstrogen receptorMedicineImmunologySteroidCancerSurgeryBreast cancerCentral Venous Catheters and HemodialysisVascular anomalies and interventionsVascular Procedures and Complications