Clinico-genomic profiling and clonal dynamic modeling of <i>TP53</i>-aberrant myelodysplastic syndrome and acute myeloid leukemia
Shyam A. Patel, Maxwell R. Lloyd, Jan Černý, Qiming Shi, Karl Simin, Asiri Ediriwickrema, Lloyd Hutchinson, Patricia M. Miron, Anne W. Higgins, Muthalagu Ramanathan, Jonathan M. Gerber
Abstract
disruption, which has implications for rational therapeutic design.
Topics & Concepts
Myeloid leukemiaEpigeneticsSomatic evolution in cancerCancer researchMyelodysplastic syndromesLeukemiaBiologySpliceosomeHypomethylating agentMedicineGeneticsGeneOncologyDNA methylationImmunologyBone marrowRNA splicingGene expressionRNAAcute Myeloid Leukemia ResearchCancer Genomics and DiagnosticsHistone Deacetylase Inhibitors Research