Synthesis of Diaryl Ethers via Hypervalent Iodine-Mediated C–H Functionalization
Chenghu Hu, Qi Jia, Wenjing Bao, Guangxing Gu, Ya Li, Yanchuan Zhao
Abstract
A hypervalent iodine-reagent-based C-H functionalization strategy was utilized to synthesize diaryl ethers. This method directly transforms various arenes into their corresponding diaryliodonium salts, followed by a C-O coupling reaction to produce structurally diverse diaryl ethers. The efficacy of this approach in the late-stage structural modifications of complex molecules was demonstrated.
Topics & Concepts
Hypervalent moleculeChemistrySurface modificationIodineReagentCombinatorial chemistryIodine compoundsMoleculeOrganic chemistryPhysical chemistryOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions