A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals
Yuying Ma, Kai S. Yang, Zhi Geng, Yugendar R. Alugubelli, Namir Shaabani, Erol C. Vatansever, R. Xinyu, Chia-Chuan Cho, Kaustav Khatua, Jing Xiao, Lauren R. Blankenship, Ge Yu, Banumathi Sankaran, Pingwei Li, Robert D. Allen, Henry Ji, Shiqing Xu, Wenshe Ray Liu
Topics & Concepts
ChemistryStereochemistryIC50ProteaseEnzymePotencyCysteine proteaseIn vitroEnzyme inhibitorBiochemistrySARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery MethodsViral Infections and Immunology Research