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Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy

Young Mi Oh, Seong Won Lee, Woo Kyung Kim, Shawei Chen, Victoria A. Church, K. Lynn Cates, Tiandao Li, Bo Zhang, Roland E. Dolle, Sonika Dahiya, Stephen C. Pak, Gary A. Silverman, David H. Perlmutter, Andrew S. Yoo

2022Nature Neuroscience93 citationsDOIOpen Access PDF

Topics & Concepts

NeuroscienceAutophagyHuntington's diseaseDiseaseNeurodegenerationPsychologyStriatumBiologyMedicineDopamineInternal medicineGeneticsApoptosisGenetic Neurodegenerative DiseasesMitochondrial Function and PathologyNeurological disorders and treatments
Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy | Litcius