Development of Diverse Range of Biologically Relevant Carbohydrate‐Containing Molecules: Twenty Years of Our Journey**
Vinod K. Tiwari
Abstract
There is an increasing demand for significant amount of carbohydrate-containing molecules owing to their complete chemical, biological, and pharmacological investigations to better understand their role in many important biological events. Clinical studies of a wide range of simple carbohydrates or their derivatives, glycohybrids, glycoconjugates, and neoglycoconjugates have been conducted worldwide for the successful treatment of various frontline diseases. Herein, a brief perspective of carbohydrate-based molecular scaffolding and my experience during the last 20 years in the area of synthetic carbohydrate chemistry, mainly for their impact in drug discovery & development, is presented.
Topics & Concepts
GlycoconjugateCarbohydrateDrug discoveryBiological activityChemistryBiochemistryCombinatorial chemistryComputational biologyBiologyIn vitroCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchClick Chemistry and Applications