Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway
Xiaofeng He, Wenjing Ma, Jing Hu, Tian-Ze Li, Chang‐An Geng, Yun‐Bao Ma, Mengfei Wang, Kexin Yang, Xue‐Mei Zhang, Ji‐Jun Chen
Abstract
Liver cancer as a common malignant tumor has become a major source of morbidity and mortality worldwide. 1 Currently, four synthetic drugs and three monoclonal antibody drugs have been approved for the treatment of hepatocellular carcinoma (HCC) since 2007. Whereas, the disadvantages of the above drugs such as low response rates, severe side effects, and drug resistance hamper their therapeutic effects. Structurally and biologically diverse natural products are a major source in the search for novel antihepatoma agents. Sesquiterpenoid dimers are a kind of important components from the genus Artemisia and exhibit remarkably cytotoxic activity. 2