The lateral plate mesoderm
Karin D. Prummel, Susan Nieuwenhuize, Christian Mosimann
Abstract
The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo. Despite this central role in development and evolution, the LPM remains challenging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definition. Here, we outline the processes that govern LPM specification, organization, its cell fates and the inferred evolutionary trajectories of LPM-derived tissues. Finally, we discuss the development of seemingly disparate organ systems that share a common LPM origin.
Topics & Concepts
BiologyMesodermLateral plate mesodermLineage (genetic)VertebrateProgenitor cellEvolutionary biologyAnatomyIntermediate mesodermHeart developmentProgenitorCell biologyStem cellGeneticsEmbryonic stem cellGeneCongenital heart defects researchZebrafish Biomedical Research ApplicationsDevelopmental Biology and Gene Regulation