Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles
Wei Tong, Hui Hui, Wenting Shang, Yingqian Zhang, Feng Tian, Qiang Ma, Xin Yang, Jie Tian, Yundai Chen
Abstract
This multimodal MPI approach revealed that active MPO-targeted nanoparticles might serve as a method for detecting vulnerable atherosclerotic plaques and monitoring MPO activity.
Topics & Concepts
Magnetic particle imagingMolecular imagingIn vivoMyeloperoxidaseVulnerable plaqueInflammationFibrous capPathologyMedicineChemistryMagnetic nanoparticlesMaterials scienceNanoparticleNanotechnologyImmunologyBiologyBiotechnologyCharacterization and Applications of Magnetic NanoparticlesCardiovascular Health and Disease PreventionBlood properties and coagulation