Computational structural optimization enhances IL13Rα2 – B7-H3 tandem CAR T cells to overcome antigen-heterogeneity-mediated tumor escape
Michaela Meehl, Kalyan Immadisetty, Vikas D. Trivedi, Paweł Głowacki, Brooke Prinzing, Alejandro Allo Anido, Jorge Ibañez-Vega, Benjamin J. Leslie, M. Madan Babu, Giedre Krenciute
Topics & Concepts
TandemChimeric antigen receptorAntigenDownregulation and upregulationCell biologyFunction (biology)In vivoComputational biologyBiologyCancer researchComputer scienceChemistryT cellImmunologyMaterials scienceBiochemistryGeneticsGeneImmune systemComposite materialCAR-T cell therapy researchNanowire Synthesis and ApplicationsViral Infectious Diseases and Gene Expression in Insects