Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer’s disease in mice
Zhengjiang Qian, Bowei Li, Xin Meng, Jianming Liao, Guangxing Wang, Yanjiao Li, Qian Luo, Keqiang Ye
Topics & Concepts
NeurodegenerationGenetically modified mouseNeprilysinPharmacologyAlzheimer's diseaseTransgeneMedicineDiseaseIn vivoPharmacokineticsAmyloid precursor protein secretaseCognitive declineNeuroscienceInternal medicineChemistryPsychologyAmyloid precursor proteinDementiaBiologyBiochemistryEnzymeGeneBiotechnologyPeptidase Inhibition and AnalysisNeuropeptides and Animal PhysiologyDiabetes Treatment and Management