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Hierarchical Multi-Stage Attention and Dynamic Expert Routing for Explainable Gastrointestinal Disease Diagnosis

Muhammad John Abbas, Hend Alshaya, Wided Bouchelligua, Nehal Hassan, Inzamam Mashood Nasir

2025Diagnostics7 citationsDOIOpen Access PDF

Abstract

Purpose: Gastrointestinal (GI) illness demands precise and efficient diagnostics, yet conventional approaches (e.g., endoscopy and histopathology) are time-consuming and prone to reader variability. This work presents GID-Xpert, a deep learning framework designed to improve feature learning, accuracy, and interpretability for GI disease classification. Methods: GID-Xpert integrates a hierarchical, multi-stage attention-driven mixture of experts with dynamic routing. The architecture couples spatial–channel attention mechanisms with specialized expert blocks; a routing module adaptively selects expert paths to enhance representation quality and reduce redundancy. The model is trained and evaluated on three benchmark datasets—WCEBleedGen, GastroEndoNet, and the King Abdulaziz University Hospital Capsule (KAUHC) dataset. Comparative experiments against state-of-the-art baselines and ablation studies (removing attention, expert blocks, and routing) are conducted to quantify the contribution of each component. Results: GID-Xpert achieves superior performance with 100% accuracy on WCEBleedGen, 99.98% on KAUHC, and 75.32% on GastroEndoNet. Comparative evaluations show consistent improvements over contemporary models, while ablations confirm the additive benefits of spatial–channel attention, expert specialization, and dynamic routing. The design also yields reduced computational cost and improved explanation quality via attention-driven reasoning. Conclusion: By unifying attention, expert specialization, and dynamic routing, GID-Xpert delivers accurate, computationally efficient, and more interpretable GI disease classification. These findings support GID-Xpert as a credible diagnostic aid and a strong foundation for future extensions toward broader GI pathologies and clinical integration.

Topics & Concepts

InterpretabilityExpert systemComputer scienceMachine learningBenchmark (surveying)Artificial intelligenceFeature (linguistics)Quality (philosophy)Routing (electronic design automation)Representation (politics)Data miningKnowledge baseFeature learningKnowledge representation and reasoningDeep learningArtificial neural networkColorectal Cancer Screening and DetectionGastrointestinal Bleeding Diagnosis and TreatmentMachine Learning in Healthcare