Self-assembled iRGD-R7-LAHP-M nanoparticle induced sufficient singlet oxygen and enhanced tumor penetration immunological therapy
Yu-e Wang, Junqiu Zhai, Yuxiu Zheng, Jiali Pan, Xiaojia Liu, Yan Ma, Shixia Guan
Abstract
, and further causes immunogenic cell death (ICD). This study demonstrates the effectiveness of exploiting biochemical reactions as a spatial-temporal strategy to overcome the current limitations of photodynamic therapy.
Topics & Concepts
Singlet oxygenPhotodynamic therapyPenetration (warfare)NanoparticleBiophysicsReactive oxygen speciesIn vivoNanoreactorChemistryPhotochemistryOxygenTumor microenvironmentPhotosensitizerMetal ions in aqueous solutionNanotechnologyMetalMaterials scienceBiochemistryCancer researchTumor cellsOrganic chemistryBiologyBiotechnologyEngineeringOperations researchNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer, Hypoxia, and Metabolism