Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients
Martina L. Reichmuth, Rico Hömke, Kathrin Zürcher, Peter Sander, Anchalee Avihingsanon, Jimena Collantes, Chloé Loiseau, Sònia Borrell, Miriam Reinhard, Robert J. Wilkinson, Marcel Yotebieng, Lukas Fenner, Erik C. Böttger, Sébastien Gagneux, Matthias Egger, Peter M. Keller
Abstract
Mutations in the genes of the F 420 signaling pathway of Mycobacterium tuberculosis complex, including dnn , fgd1 , fbiA , fbiB , fbiC , and fbiD , can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes.
Topics & Concepts
Mycobacterium tuberculosisTuberculosisBiologyDrug resistanceGeneticsMutationExtensively drug-resistant tuberculosisGeneMicrobiologyVirologyMedicineMultiple drug resistancePathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisBiochemical and Molecular Research