A novel Toll-like receptor 7/8–specific antagonist E6742 ameliorates clinically relevant disease parameters in murine models of lupus
Sally T. Ishizaka, Lynn D. Hawkins, Qian Chen, Fumitoshi Tago, Takuya Yagi, Kentaro Sakaniwa, Zhikuan Zhang, Toshiyuki Shimizu, Manabu Shirato
Topics & Concepts
Systemic lupus erythematosusAntagonistDiseaseToll-like receptorReceptor antagonistImmunologyMedicineInterleukin 1 receptor antagonistReceptorPharmacologyInternal medicineInnate immune systemImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsMacrophage Migration Inhibitory Factor