Combination of Miconazole and Domiphen Bromide Is Fungicidal against Biofilms of Resistant <i>Candida</i> spp
Jana Tits, Freya Cools, Kaat De Cremer, Katrijn De Brucker, Judith Berman, Kristof Verbruggen, Bert Gevaert, Paul Cos, Bruno P.A. Cammue, Karin Thevissen
Abstract
The occurrence and recurrence of mucosal biofilm-related Candida infections, such as oral and vulvovaginal candidiasis, are serious clinical issues. Vaginal infections caused by Candida spp., for example, affect 70 to 75% of women at least once during their lives. Miconazole (MCZ) is the preferred topical treatment against these fungal infections, yet it has only moderate antibiofilm activity. Through screening of a drug-repurposing library, we identified the quaternary ammonium compound domiphen bromide (DB) as an MCZ potentiator against Candida biofilms.
Topics & Concepts
MiconazoleBiofilmMicrobiologyFungicideMiconazole NitrateAntimicrobialVulvovaginal CandidiasisAntifungalPotentiatorMedicineBiologyPharmacologyBacteriaGeneticsBotanyAntifungal resistance and susceptibilityFungal Infections and StudiesAntimicrobial agents and applications