Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract
Sabrina I. Green, Carmen Gu Liu, Xue Yu, Shelley Gibson, Wilhelm Salmen, Anubama Rajan, Hannah E. Carter, Justin R. Clark, Xuezheng Song, Robert F. Ramig, Barbara W. Trautner, Heidi B. Kaplan, Anthony W. Maresso
Abstract
Invasive pathobionts or microbes capable of causing disease can reside deep within the mucosal epithelium of our gastrointestinal tract. Targeted effective antibacterial therapies are needed to combat these disease-causing organisms, many of which may be multidrug resistant.
Topics & Concepts
Gastrointestinal tractGlycanPhage therapyMicrobiologyDiseaseBiologyMedicineBacteriophagePathologyGlycoproteinEscherichia coliMolecular biologyGeneBiochemistryBacteriophages and microbial interactionsGlycosylation and Glycoproteins ResearchProbiotics and Fermented Foods