Chromatin Conformation in Development and Disease
Ilias Boltsis, Frank Grosveld, Guillaume Giraud, Petros Kolovos
Abstract
Chromatin domains and loops are important elements of chromatin structure and dynamics, but much remains to be learned about their exact biological role and nature. Topological associated domains and functional loops are key to gene expression and hold the answer to many questions regarding developmental decisions and diseases. Here, we discuss new findings, which have linked chromatin conformation with development, differentiation and diseases and hypothesized on various models while integrating all recent findings on how chromatin architecture affects gene expression during development, evolution and disease.
Topics & Concepts
ChromatinChIA-PETBiologyComputational biologyRegulation of gene expressionGene expressionChromatin remodelingScaffold/matrix attachment regionBivalent chromatinDiseaseGeneEvolutionary biologyGeneticsCell biologyMedicinePathologyGenomics and Chromatin DynamicsChromatin Remodeling and CancerRNA Research and Splicing