Associations of urinary 8‐iso‐prostaglandin F<sub>2α</sub> levels with all‐cause dementia, Alzheimer's disease, and vascular dementia incidence: results from a prospective cohort study
Kira Trares, Xīn Gào, Laura Perna, Dan Rujescu, Hannah Stocker, Tobias Möllers, Konrad Beyreuther, Hermann Brenner, Ben Schöttker
Abstract
Abstract Introduction Prospective studies on a potential association of 8‐iso‐prostaglandin F 2α (8‐iso‐PGF 2α ) levels, a biomarker of lipid peroxidation, with dementia are limited. Methods Multivariate Cox regression models were used to assess potential associations of urinary 8‐iso‐PGF 2α levels with all‐cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population‐based cohort. Results Over 14 years of follow‐up, 365 all‐cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8‐iso‐PGF 2α tertile had a 45% increased risk of all‐cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected ( P = .02). Furthermore, continuously modeled, logarithmized 8‐iso‐PGF 2α levels were statistically significantly associated with all‐cause dementia and AD incidence. Discussion Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8‐iso‐PGF 2α levels and the APOE ԑ4/ԑ4 genotype showed a considerably increased dementia risk.