Engineering a brain-targeted AKBA conjugate to attenuate post-stroke deficits by inhibiting GSTO1-dependent astrocytic pyroptosis
Qian Meng, Chen Huang, Min Bai, Yucheng Liao, Kun Zhang, Yiwen Wang, Jingwen Wang, Le Yang, Yi Ding
Topics & Concepts
PyroptosisRegulatorConjugateChemistryNeuroinflammationGene knockdownPharmacologyIn vivoCell biologyStroke (engine)CrosstalkPathogenesisNeuroscienceMedicinePresenilinIschemic strokeCancer researchBiologyBiochemistryImmunofluorescenceGenetic enhancementSurface plasmon resonanceBlood–brain barrierInflammasome and immune disordersKruppel-like factors researchCholesterol and Lipid Metabolism