The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3
Eutteum Jeong, José A. Martina, Pablo S. Contreras, Juhyung Lee, Rosa Puertollano
Abstract
sodium arsenite; POLR2, RNA polymerase II; PPARGC1A, PPARG coactivator 1 alpha; PYROXD1, pyridine nucleotide-disulfide oxidoreductase domain 1; RRAGC, Ras related GTP binding C; SEC13, SEC13 homolog, nuclear pore and COPII coat complex component; SLC38A9, solute carrier family 38 member 9; SSRP1, structure specific recognition protein 1; SUPT16H, SPT16 homolog, facilitates chromatin remodeling subunit; TFEB, transcription factor EB; TFE3, transcription factor binding to IGHM enhancer 3; TXNRD1, thioredoxin reductase 1; UVRAG, UV radiation resistance associated; WDR59, WD repeat domain 59.
Topics & Concepts
TFEBTranscription factorBiologyCell biologyChromatinBasic helix-loop-helix leucine zipper transcription factorsRegulation of gene expressionTranscriptional regulationEnhancerGeneGeneticsDNA-binding proteinGenomics and Chromatin DynamicsUbiquitin and proteasome pathwaysDNA Repair Mechanisms