Fatty Acid Metabolism and Idiopathic Pulmonary Fibrosis
Jing Geng, Yuan Liu, Huaping Dai, Chen Wang
Abstract
synthesis, uptake, oxidation, and derivation of fatty acids, plays several important roles at cellular and organ levels. Recent studies have identified characteristic changes in fatty acid metabolism in idiopathic pulmonary fibrosis (IPF) lungs, which implicates its dysregulation in the pathogenesis of this disorder. Here, we review the evidence for how fatty acid metabolism contributes to the development of pulmonary fibrosis, focusing on the profibrotic processes associated with specific types of lung cells, including epithelial cells, macrophages, and fibroblasts. We also summarize the potential therapeutics that target this metabolic pathway in treating IPF.
Topics & Concepts
Idiopathic pulmonary fibrosisFatty acid metabolismMetabolismPathogenesisFibrosisPulmonary fibrosisFatty acidBeta oxidationCell metabolismLungMetabolic pathwayMedicineBiologyChemistryBiochemistryPathologyInternal medicineInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and TreatmentsMedical Imaging and Pathology Studies