APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy
Yu Du, Yu Zhou, Xinyu Yan, Feiyan Pan, Lingfeng He, Zhigang Guo, Zhigang Hu
Topics & Concepts
GPX4Cancer researchDownregulation and upregulationProgrammed cell deathProtein kinase BLipid peroxidationDNA damageDNA repairChemistryCell biologyBiologyPhosphorylationApoptosisOxidative stressBiochemistryDNASuperoxide dismutaseGeneGlutathione peroxidaseFerroptosis and cancer prognosisRNA modifications and cancerMicroRNA in disease regulation