MiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2
Xiaowen Cao, Fangsu Xue, Haoyu Chen, Lu Shen, Xiaosa Yuan, Yunchi Yu, Ying Zong, Lou Zhong, Fang Huang
Abstract
Background: Lung adenocarcinoma (LUAD) is the most common type of lung cancer, and its pathogenesis is still unclear. The present study aimed to investigate the role of miR-202-3p and its downstream target gene, ribonucleotide reductase regulatory subunit M2 (RRM2), in the occurrence and development of LUAD and elucidate the correlation between RRM2 and the clinicopathological stage and prognosis of LUAD.
Topics & Concepts
AdenocarcinomaLung cancerCancer researchmicroRNAA549 cellBiologyCell growthMetastasisDownregulation and upregulationCancerMedicineOncologyGeneGeneticsRNA modifications and cancerCancer-related molecular mechanisms researchMicroRNA in disease regulation