Identification of novel bacterial urease inhibitors through molecular shape and structure based virtual screening approaches
Muhammad Imran, Saba Waqar, Koji Ogata, Mahmood Ahmed, Zobia Noreen, Sundus Javed, Nazia Bibi, Habib Bokhari, Asma Amjad, Muhammad Muddassar
Abstract
The enzyme urease is an essential colonizing factor of the notorious carcinogenic pathogen <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>), conferring acid resistance to the bacterium.
Topics & Concepts
UreaseVirtual screeningEnzymeHelicobacter pyloriChemistryDocking (animal)BacteriaIC50PathogenBiochemistryMicrobiologyCombinatorial chemistryIn vitroBiologyDrug discoveryNursingMedicineGeneticsMicrobial Applications in Construction MaterialsPeptidase Inhibition and AnalysisComputational Drug Discovery Methods