Chronic Lithium Therapy and Urine-Concentrating Ability in Individuals With Bipolar Disorder: Association Between Daily Dose and Resistance to Vasopressin and Polyuria
Nahid Tabibzadeh, Emmanuelle Vidal‐Petiot, Lynda Cheddani, Jean‐Philippe Haymann, Guillaume Lefèvre, Bruno Étain, Frank Bellivier, Emeline Marlinge, Marine Delavest, François Vrtovsnik, Martin Flamant
Abstract
Introduction: Lithium treatment can induce nephrogenic diabetes insipidus (NDI), but no consensus intervention is offered to date. We evaluated in these patients patterns of urine concentration and the correlates of 24-hour urine output. Methods: 119), and measured glomerular filtration rate (mGFR). Maximal urine osmolality (MaxUosm) was the highest level during the DDAVP test. Results: = 0.03). Conclusion: Higher lithium daily dose was associated with higher vasopressin levels and higher urine output, independently of other factors. Daily osmolar intake was also associated with higher 24-hour urine output. These results suggest that controlled salt and protein intake and lithium dose might reduce polyuria in these patients.