Imidazo[1,2-a]quinazolines as novel, potent EGFR-TK inhibitors: Design, synthesis, bioactivity evaluation, and in silico studies
Zaman Hasanvand, Tayebeh Oghabi Bakhshaiesh, Fariba Peytam, Loghman Firoozpour, Elaheh Hosseinzadeh, Rasoul Motahari, Setareh Moghimi, Elaheh Nazeri, Mahsa Toolabi, Farhad Momeni, Hamid Reza Bijanzadeh, Ali Khalaj, Blandine Baratte, Béatrice Josselin, Thomas Robert, Stéphane Bach, Rezvan Esmaeili, Alireza Foroumadi
Topics & Concepts
ChemistryIn silicoPharmacologyEGFR inhibitorsComputational biologyCombinatorial chemistryBiochemistryEpidermal growth factor receptorReceptorGeneBiologyMedicineQuinazolinone synthesis and applicationsLung Cancer Treatments and MutationsSynthesis and Biological Evaluation