Innovative transdermal delivery of insulin using gelatin methacrylate-based microneedle patches in mice and mini-pigs
Bilal Demir, Léa Rosselle, Anna Voronova, Quentin Pagneux, Audrey Quenon, Valéry Gmyr, Dorothée Jary, Nathalie Hennuyer, Bart Staels, Thomas Hübert, Amar Abderrahmani, Valérie Plaisance, Valérie Pawlowski, Rabah Boukherroub, Séverine Vignoud, Sabine Szunerits
Abstract
-MN patches reduces blood glucose levels in C57BL/6 mice and mini-pigs comparably to subcutaneously injected insulin. We believe that this on-demand delivery system might alter the current insulin therapies and might be a potential approach for delivery of other proteins.
Topics & Concepts
TransdermalGelatinInsulin deliveryMethacrylateMedicineInsulinPharmacologyBiomedical engineeringChemistryMaterials scienceDiabetes mellitusInternal medicineEndocrinologyBiochemistryComposite materialType 1 diabetesPolymerCopolymerAdvancements in Transdermal Drug DeliveryBee Products Chemical AnalysisAdvanced Drug Delivery Systems