Development of dual aptamers-functionalized c-MET PROTAC degraders for targeted therapy of osteosarcoma
Xuekun Fu, Jie Huang, Xinxin Chen, Duoli Xie, Hongzhen Chen, Zhijian Liang, Zhuqian Wang, Yiying Liang, Aiping Lü, Chao Liang
Abstract
This study suggests that the AS1411-SL1 chimeras could be promising c-MET degraders for targeted therapy of OS.
Topics & Concepts
AptamerOsteosarcomaTargeted therapyCancer researchMedicineChemistryCancerBiologyInternal medicineMolecular biologyProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisMultiple Myeloma Research and Treatments